Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis



 - Renal disease, Cardiovascular disease -> Decreased renal blood flow

 - Cirrhosis, Nephrosis, Heart failure, Diuretics -> Decreased blood volume



-> Increased vasoconstrictors: Angiotensin II, Catecholamines, Vasopressin



NSAlDs inhibit prostaglandin synthesis, leaving actions of Vasoconstrictors unopposed.



#NSAIDs #Prostaglandins #Pharmacology #Pathophysiology