- Post-cavernosal venous occlusion -> Post-cavernosal venous drainage is mechanically obstructed e.g. sickle cell disease, dialysis etc.
- Increased nitric oxide from cavernous nerve plexus and cavernosal sinus endothelia -> Trabecular smooth muscle relaxes, Cavernosal artery smooth muscle relaxes -> Post-cavernosal venules are compressed against tunica albuginea
- Impaired detumescence (erection-ending) pathways -> Lack of norepinephrine action on penile SM -> Trabecular smooth muscle and cavernosal artery smooth muscle do not contract
-> Ischemic (Low-flow): Inadequate venous function
-> Blood pools in corpora cavernosa
-> Increased pressure in corpora
Prolonged erection lasting more than 4 hours; in absence of sexual stimulation; not relieved by ejaculation
#Priapism #Pathophysiology #Urology #Diagnosis