Pseudogout: pathogenesis and clinical findings
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Description

Pseudogout: pathogenesis and clinical findings

 - Idiopathic (vast majority of cases) -> Mechanism unknown

 - Familial chondrocalcinosis -> Overactivity of the NTPPPH enzyme and mutations in the ANKH gene, Incr pyrophosphate production

 - Hyperparathyroidism -> Incr levels of parathyroid hormone produced, incr gut Ca2+ absorption

 - Hemochromatosis -> Clearance of calcium pyrophosphate dihydrate (CPPD) crystals from joints is inhibited by iron

 - Hypomagnesia -> The relative absence of magnesium impairs pyrophosphatase activity, reduces pyrophosphate breakdown

 - Hypophosphatasia -> Defective mineralization of calcium and phosphorous in bones



 - Chondrocalcinosis, seen on high-resolution ultrasound and/or x-ray

 - CPPD Crystals - Positively birefringent (crystals appear blue parallel to axis of polarizer)

 - PAINFUL, warm, swollen joint (sudden onset)

 - Incr C-reactive protein (CRP); erythrocyte sedimentation rate (ESR)

 - Subchondral sclerosis & cysts, joint space narrowing, and osteophytes seen on x-ray



#Chondrocalcinosis #Pseudogout #CPPD #Disease #Signs #Symptoms #Pathophysiology #Diagnosis
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The Calgary Guide to Understanding Disease
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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