Gout: Pathogenesis and Clinical Findings
 - Conditions ...
1.1K
Description

Gout: Pathogenesis and Clinical Findings

 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders

 - Medications (ASA, ACE- inhibitors, cyclosporine, diuretics)

 - Alcohol Intake -> Alcohol is -> catabolized into ketones and lactic acid -> Ketones and lactic acid compete with uric acid for excretion in urine, excretion of uric acid



-> Incr uric acid concentration in blood, easily leaks into joints -> Uric acid crystallizes in a peripheral joint -> Activation of complement cascade results in leukocyte chemotaxis -> Neutrophils enter joint to phagocytose the crystal -> Needle-shaped uric acid crystals puncture neutrophils, releasing degradative enzymes into joint space -> Chronic tophaceous gout



#Hyperuricemia #Pathophysiology #Complications #Gout #Tophaceous #Tophi
Contributed by

The Calgary Guide to Understanding Disease
@TheCalgaryGuide
Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
0 Comments

Related content