Third Generation Antipsychotics: Mechanisms and Side Effects

(Atypical Anti-Psychotics) Example: Aripiprazole

Dopamine D2 Receptor Partial Agonist

 • Binds to the D2 receptor, then very quickly releases, then re-binds. This repetitive binding pattern does not allow for the normal dopamine molecules in the synapse to bind to the D2 receptor 

 • Prevents excess DA from over-stimulating receptors, and deficient DA from under-stimulating receptors

Serotonin 1A Partial Agonist

 • Bind to 5-HT 1A receptor in stabilizing manner, similar to D2-receptor agonism; does not allow excess or deficient 5-HT to over-stimulate or under-stimulate receptors

 • Antidepressant Effects



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