Hypocalcemia - Differential Diagnosis Algorithm - Low ...
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Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate

LOW PHOSPHATE

 - Low/NormaI PTH

    • Severe Malnutrition with Hypomagnesemia

 - High PTH

    • Vitamin D Deficiency (e.g. Diet, Malabsorption, Phenytoin, Nephrotic Syndrome, Hepatobiliary Disease)

    • Hereditary Vitamin D Resistance

    • 1-alpha-hydroxylase Deficiency

HIGH PHOSPHATE

 - Normal Creatinine - Low/NormaI PTH

    • Hypoparathyroidism (e.g. Acquired, Autoimmune, Idiopathic, Congenital, Infiltrative)

    • Activating Mutation in Calcium Sensing Receptor (CaSR)

    • Hypomagnesemia

 - Normal Creatinine - High PTH

    • PTH Resistance (Pseudo-hypoparathyroidism)

    • Calcium Complexing

    • (Citrate Infusion, Pancreatitis)

 - High Creatinine - Low PTH

    • Hypoparathyroidism with Chronic Kidney Disease

 - High Creatinine - High PTH

    • Secondary Hyperparathyroidism

    • Rhabdomyolysis

    • Phosphate Poisoning



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