Short Stature - Differential Diagnosis Algorithm

Normal Variant, Normal Puberty Onset (BA = CA)

 • Familial Short Stature

Normal Variant, Delayed Puberty Onset (BA < CA)

 • Constitutional Short Stature (Late Bloomer)

Disproportionate

 • Skeletal Dysplasias

 • (e.g. Achondroplasia)

 • Rickets

Dysmorphic Features

  • Trisomy 21

  • Noonan Syndrome

  • Prader-Willi Syndrome

  • Russell-Silver Syndrome

  • Turner Syndrome

Deprivation

 • Primary Malnutrition

 • Psychosocial

 • Deprivation

Endrocrine

 • Cushing's Disease

 • GH Deficiency

 • IGF-I Deficiency (e.g. Laron Dwarfism)

 • Hypothyroidism

 • Congenital Adrenal Hyperplasia

 • Panhypopituitarism

Treatment

 • Glucocorticoids

 • Radiation

 • Chemotherapy

 • Bone Marrow Transplant

Chronic Disease

 • GI (e.g. Celiac, IBD)

 • Renal (e.g. CRF)

 • Infection (e.g. Chronic UTI)

 • Cardiopulmonary (e.g. Cystic Fibrosis, CHF)

 • Inborn Metabolism Error

 • Immunologic 

Other

 • Intrauterine Growth Retardation

 • Bulimia Nervosa

 • Anorexia Nervosa

 • CNS Tumors (e.g. Craniopharyngioma)



#ShortStature #Differential #Diagnosis #Algorithm #endocrinology #causes #pediatrics