Tall Stature - Differential Diagnosis Algorithm



Normal Growth (BA=CA)

 • Familial Tall Stature

 • XYY Syndrome

Obese BMI

 • Exogenous Obesity

Normal Puberty Onset

 • GH Excess

 • Hyperthyroidism

Precocious Puberty

 • Adrenal Tumor

 • Ovarian Tumor

 • Testotoxicosis

 • Congenital Adrenal Hyperplasia

Constitutional

 • Constitutional Tall Stature (Early Bloomer)



Other Obvious Abnormalities/Stigmata - Disproportionate

 • Klinefelter's Syndrome

 • Soto's Syndrome/ Cerebral Gigantism

 • Marfan's Syndrome

 • Homocystinuria

 • Sex Steroid Deficiency/Resistance

 • Acromegaly (Rare in Children)

Other Obvious Abnormalities/Stigmata - Proportionate

 • Bechwith-Weidmann Syndrome (Normalizing growth after birth)

 • Weaver Syndrome

 • XYY Syndrome

 • Neurofibromatosis 1

 • Hyperthyroidism (Untreated/Severe)



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