Causes of Generalized Edema - Differential Diagnosis Algorithm

Overfill (Increased renal sodium retention, Urine Na > 40meq/L)

 • NSAlDs

 • AKI/CKD

 • Nephrotic Syndrome

Increased Interstitial Oncotic Pressure

 • Myxedema (Hypothyroid)

Increased Capillary Hydrostatic Pressure

 • Right heart failure

 • Constrictive pericarditis

 • Portal hypertension

 • Pregnancy

Decreased Capillary Oncotic Pressure

 • Nephrotic syndrome

 • Cirrhosis

Increased Capillary Permeability

 • Inflammation

 • Sepsis

 • Acute Respiratory Distress Syndrome

 • Allergies

 • Burns/Trauma



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