Causes of Bleeding / Bruising - Differential Diagnosis Algorithm

Thrombocytopenia - Quantitative Defect

 • Decreased Production

 • Increased Destruction

 • Abnormal Sequestration

Disordered Platelet Function - Qualitative Defect

 • Congenital - Rare

 • Drugs (e.g. ASA)

 • Renal Disease

Vascular System - Congenital

 • Connective Tissue Disorders

 • Hereditary TeIangiectasia

Vascular System - Acquired

 • Steroids

 • Vasculitis

Coagulation Proteins - Congenital

 • Factor VIII Deficiency

 • Factor IX Deficiency

 • Von Willebrand's Disease

 • Other deficiencies

Coagulation Proteins - Acquired

 • Anticoagulation (Iatrogenic)

 • Liver Disease

 • Vitamin K Deficiency

 • Disseminated Intravascular Coagulation



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