Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 ...
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Causes of Splenomegaly - Differential Diagnosis Algorithm

Infectious

 • Bacterial

 • Viral (EBV)

 • Parasitic

 • Fungal

Congestive

 • Cirrhosis

 • Thrombus (e.g. Hepatic, Portal, Splenic)

Infiltrative - Non-Malignant

 • Amyloidosis

 • Gaucher's Disease

 • Glycogen Storage Disease

Infiltrative - Malignant

 • Lymphoma

 • Leukemia

 • Myeloproliferative disorders (eg. polycythemia vera, essential thrombocytosis, myelofibrosis)

Inflammatory

 • Systemic Lupus Erythematosus

 • Sarcoidosis

 • Felty's Disease

 • Serum Sickness

Hemolytic Disease

 • Sickle Cell Disease (children)

 • Thalassemia

 • Congenital Spherocytosis

 • Acquired causes



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