Causes of Intrauterine Growth Restriction / Small for ...
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Description

Causes of Intrauterine Growth Restriction / Small for Gestational Age - Differential Diagnosis Algorithm

Fetal Factors:

 - TORCH Infections

 - Chromosomal

 - Multiple Gestation

 - Abnormalities

     • Trisomy 13, 18, 21

     • Turner syndrome, 45X

Placental Factors:

 - Placental Ischemia / Infarction

     • Placenta previa

     • Chronic insufficiency

 - Placental Abruption

 - Placental Malformations - Vasa previa

 - Confined Placental Mosaicism (Rare)

Maternal Factors:

 - Decreased Uteroplacental Flow

     • Gestational hypertension / Pre-eclampsia

     • Renal insufficiency

     • Diabetes mellitus

     • Autoimmune disorders

 - Maternal Lifestyle

     • Malnutrition

     • Smoking

     • Alcohol

     • Drugs

 - Maternal Hypoxemia

     • Pulmonary diseases

     • Chronic anemia

     • High altitude

 - Iatrogenic

     • Folic acid antagonists

     • Anticonvulsants



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