Causes of Recurrent Pregnancy Loss - Differential Diagnosis Algorithm

Environmental:

 • Toxin (organic solvents, mercury, lead)

 • Smoking

 • Alcohol

 • Drugs

 • Ionizing radiation

Other:

 • Maternal infection

 • Thrombophilia

Autoimmune:

 • Antiphospholipid syndrome

 • Lupus anticoagulant

Endocrine:

 • Diabetes mellitus

 • Hypo/hyperthyroidism

 • PCOS

 • Luteal phase deficiency

Genetic:

 • Maternal age

 • Maternal / paternal chromosomal abnormality

Cervix:

 • Cervical insufficiency

Uterus:

 • Fibroids

 • Congenital anomaly

 • Polyps

 • Asherman's Syndrome



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