Causes of Hypotonic Infant (Floppy Newborn) - Differential ...
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Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm

Central Nervous System - Decreased LOC, Axial Weakness, Normal Strength, Normal Reflexes

 - Brain

     • Hypoxic-Ischemic Encephalopathy*

     • Trisomy 21*

     • Intracranial Hemorrhage

     • CNS Infection

     • Metabolic Diseases

     • Prader-Willi

     • Intracranial Mass/lesion

     • Other Congenital Syndromes

 - Spinal Cord

     • Spinal Muscular Atrophy

     • Trauma

     • Hematoma

     • Abscess

     • Arteriovenous Fistula

     • Infantile Neuronal Degeneration

     • Poliomyelitis

Peripheral Nervous System - Alert, Responding to Surroundings, Profound Peripheral Weakness

 - Nerves

     • Congenital Hypomyelinating Neuropathy

     • Infantile Neuroaxonal Degeneration

 - Neuromuscular Junction

     • Congenital and Transient Myasthenia Gravis

     • Infantile Botulism

     • Magnesium Toxicity

     • Aminoglycoside Toxicity

 - Muscle

     • Congenital Myotonic Dystrophies

     • Metabolic Myopathies

     • Central Core Disease

     • Other Congenital Myopathies



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