Clinical Characteristics of Simple vs Complex Cutaneous Leishmaniasis 

Simple CL

 - Caused by a Leishmania species unlikely to be associated with mucosal leishmaniasis

 - No mucosal involvement noted

 - Only a single or a few skin lesions

 - Small lesion size (diameter <1 cm)

Complex CL: Caused by a Leishmania species that can be associated with increased risk for ML, particularly Viannia spp in the “mucosal belt” of Bolivia, Peru, and Brazil

 - Local subcutaneous nodules, Large regional adenopathy

 - >4 skin lesions of substantial size (eg, >1 cm), Large individual skin lesion (diameter ≥5 cm)



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