IDSA Diabetic Foot infection - In Which Situations Is Diagnostic Bone Biopsy Most Recommended?

 • Patient or provider prefers definitive diagnosis to justify choice of early surgery in favor of prolonged treatment

 • Cultures of soft tissue or blood suggest high risk of osteomyelitis with antibiotic-resistant organism(s)

 • There is progressive bony deterioration or persistently elevated inflammatory markers during empiric or culture directed therapy (should consider surgical resection)

 • Suspect bone is a planned target for insertion of orthopaedic metalware



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