Blood Disorders - Markers and Differential Diagnosis Algorithm 

Acute

 • Myloid (AML) - CD13, CD33, CD34, HLA-DR, MPO, Sudan Black, Auer rod

 • Lymphoid (ALL) - PAS, TdT Lymphadenopathy, CNS Involvement

     - B-cell - CD19, CD22, CD10 

     - T-cell - CD7, CD3

Chronic

 • Myloid Disorders

     - Myelodysplastic Disorder - Abnormal morphology, Pseudo Pelger-Huet, Macrocytic anemia

     - Myeloproliferation Disorder - Abnormal Proliferation

 • Lymphoid (CLL) - CD38(new), Light chain restriction (κ or λ), Smudge Cells

     - B-cell CD5, CD19, CD20, CD23,

         o CML - bcr-able (+) ↑ WBC

         o Other bcr-able (-) - Polycythemia Vera (PV), Essential Thrombocytosis (ET), Myelofibrosis (MF), Reactive Thrombocytosis

     - T-cell



- Amy Chung, MD, MSc @AmyChung 



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