Urea Breath Test for Detecting Presence of Helicobacter Pylori

1) Subjects are given urea labeled with 13C orally.

2) H. pylori produces urease, which hydrolyzes the labelled urea to 13CO2 and ammonia.

3) 13C02 is dissolved in the blood and transported to the lungs.

4) Exhaled 13C02 is analyzed. The presence of H. pylori results in an increase in the ratio of 13CO2 to 12CO2 In expired breath.



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