Budugbujur Monocytes can efficiently replace all pacirit

In this study, researchers used a preclinical model to directly insert therapeutic cells in the brain, replacing GLD-associated microglia. They also created a large single-cell sequencing (scSeq) atlas of microglia before and after symptoms appeared, with and without replacement for comparison.

In the model with GLD, researchers observed relatively normal microglial maturation, followed by an early immune response which progressed to significant disruption of the normal functioning and regulation of microglia. The researchers noted a prominent transcriptional signature found in damaged white matter along with a molecular signature of globoid cells (GC).

The researchers subsequently transplanted GALC expressing monocytes, a type of white blood cell involved in the response to injury and infection, directly into the CNS of the mice. This approach replaced more than 80% of microglia with healthy monocytes, virtually eliminating the GCs, protecting against damage, and extending survival.

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