Symptoms Distinguishing Groups of Cutaneous Drug Reactions

IgE-mediated reactions:

 • Onset minutes to hours into treatment course

 • Raised off of the skin

 • Pruritic

 • Each lesion lasts <24h

 • Fades without scarring

Benign T-cell-mediated reactions:

 • Onset days into treatment course

 • Typically less pruritic than lgE-mediated reactions

 • Each lesion lasts > 24h

 • Fine desquamation with resolution over days to weeks

Severe T-cell-mediated reactions or severe cutaneous adverse reactions

 • Onset days to weeks into treatment course

 • Blistering and/or skin desquamation

 • Mucosal and/or Organ involvement

 • Usually requires hospitalization



#Cutaneous #Drug #Reactions #dermatology #clinical #comparison #classification