Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)

SLE patient develops new:

 • Proteinuria > 500 mg/d

 • Nephritic urine sediment (dysmorphic RBCs, RBC casts, WBC casts) especially if combined with evidence of proteinuria

 • Decreased kidney function (attributable to SLE)

→ Perform Kidney Biopsy

 • Non-ProIiferative LN

 • Proliferative LN

 • Non-LN Kidney Disease (5%)



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