Mechanism of Action of Bile Acid Sequestrants

Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool → ↑ Hepatic Bile Acid Synthesis from Cholesterol → ↓ Intrahepatic Cholesterol Pool

→ ↑ HMG-CoA Reductase Expression → ↑ VLDL Production/Secretion → ↑ LDL Production

→ ↑ LDL Receptors → ↑ LDL Clearance → ↓ Plasma LDL-C



#biliary #acid #sequestration #pathophysiology #pharmacology #bileacid