Pulmonary Hypertension Groups - WHO Classification

Group I - Vascular remodeling of pulmonary arteries

 • Idiopathic, HIV, connective tissue disorders

Group II - Left-sided heart disease causing back up of blood flow

 • Left heart failure, aortic valve disease, mitral valve disease

Group III - Chronic lung disease causing hypoxemia

 • COPD, ILD, sleep apnea

Group IV - CTEPH

 • Pulmonary Embolism

Group V - Unclear and multifactorial

 • Sarcoidosis, chronic hemolytic anemia, thyroid disorders, sickle cell anemia, splenectomy, mediastinal tumors, chronic renal failure on hemodialysis

WHO PH Functional Classification

I - No limitation of usual physical activity

II - No issues at rest, but normal activity worsens dyspnea, fatigue, or chest pain.

III - No issues at rest, but normal activity is markedly limited by dyspnea, fatigue, chest pain, or pre-syncope.

IV - Unable to perform activity at rest. Symptoms of right ventricular failure might be present at rest.



- Dr. Rishi Kumar @rishikumarmd



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