Acute Schistosomiasis: Katayama Fever

 • Most common in travelers and children

 • "Swimmers Itch" in the lower extremities, papular or urticarial rash

 • Systemic hypersensitivity reaction to the schistosome antigens and circulating immune complexes—coincides with beginning of egg production and rapid increase in Ag burden (3-8 weeks post exposure)

 • Fever, myalgias, arthralgias, diarrhea, abdominal pain, headache, rarely angioedema. Hepatomegaly and splenomegaly

 • Eosinophilia in 30-60%



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