Review of the Coagulation Cascade
Traditional Model:

Review of the Coagulation Cascade

Traditional Model:

 • Parallel extrinsic and intrinsic pathways.

Contemporary Model:

 • 4 key multicomponent complexes, each of which consists of an activated clotting factor enzyme, a cofactor, and the enzyme substrate.

 • Initiation phase caused by tissue factor's exposure due to vascular injury

 • Followed by the amplification phase (dependent upon intrinsic X-ase; factors VIII & IX)

End result in both models (i.e. common pathway): Thrombin converts fibrinogen to fibrin, which is cross-linked by Factor XIIIa, resulting in coagulation

- Dr. Eric Strong @DrEricStrong - Strong Medicine

#Coagulation #Cascade #diagnosis #models #hematology #pathophysiology
Contributed by

Dr. Gerald Diaz
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: | Twitter:
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