Review of the Coagulation Cascade
• Parallel extrinsic and intrinsic pathways.
• 4 key multicomponent complexes, each of which consists of an activated clotting factor enzyme, a cofactor, and the enzyme substrate.
• Initiation phase caused by tissue factor's exposure due to vascular injury
• Followed by the amplification phase (dependent upon intrinsic X-ase; factors VIII & IX)
End result in both models (i.e. common pathway): Thrombin converts fibrinogen to fibrin, which is cross-linked by Factor XIIIa, resulting in coagulation
- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/
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