Thiamine Deficiency - Manifestations and Differential Diagnosis
Deficiency:
 • Poor intake: Diets high in polished rice/processed grains, chronic alcoholism, TPN, Gastric bypass surgery
 • Poor absorption: Malnutrition, Gastric bypass surgery, Malabsorption
 • Increased loss: Diarrhea, hyperemesis gravidarum, Diuretic use, renal replacement therapy
 • Increased thiamine utilization: Pregnancy, Lactation, Hyperthyroidism, Refeeding syndrome
 • Diuretics, other drugs
Wernicke- Kosakoff syndrome:
 • Wernicke's Encephalopathy - Acute neurological condition: Nystagmus, Ophthalmoplegia, Ataxia / confusion
 • Korsakoff syndrome - Chronic neurological condition: Impaired short term memory, confabulation
 • WE+memory loss & psychosis with confabulation is consistent with WKS

#Thiamine #Deficiency #Manifestations #Differential #Diagnosis #causes #syndromes #beriberi #nutrition