Von Willebrand Disease Classification

Type 1 (Accounts for ~3/4 of cases):

 • Defect: Quantitative defect (i.e. not enough VWF)

 • Inheritance: Autosomal dominant

 • Bleeding: None-severe

Type 2 (Type 2A, 2B, 2M, 2N):

 • Defect: Qualitative defect (i.e. dysfunctional VWF)

 • Inheritance: Autosomal dominant (common), Autosomal recessive (uncommon)

 • Bleeding: Moderate-severe

Type 3 (Accounts for <5% of cases):

 • Defect: Profound quantitative defect (i.e. a total or near total absence of vWF)

 • Inheritance: Autosomal recessive

 • Bleeding: Severe (Clinically similar to hemophilia A)



- Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedicalLectures/



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