Duke's Criteria for Infective Endocarditis
Definite IE - Pathologic Criteria:
 • Pathologic lesions - vegetation or intracardiac abscess demonstrating active endocarditis on histology OR
 • Microorganism - demonstrated by culture or histology of a vegetation or intracardiac abscess
Definite IE - Clinical Criteria:
 • 2 major clinical criteria OR
 • 1 major and 3 minor clinical criteria OR
 • 5 minor criteria
Possible IE:
 • Presence of 1 major and 1 minor clinical criteria OR
 • Presence of 3 minor clinical criteria
Major Criteria:
 • Positive blood cultures for IE
     - Typical microorganisms consistent with IE from 2 separate blood cultures
     - Persistently positive blood culture
     - Single positive blood culture for Coxiella burnetii or phase I IgG antibody titer > 1:800
 • Evidence of endocardial involvement
     - Echocardiogram positive for IE
     - New valvular regurgitation
Minor Criteria:
 • Predisposition
 • Fever
 • Vascular phenomena
 • Immunologic phenomena
 • Micro: + bcxs that do not meet major criteria OR serologic evidence of active infection with organism consistent with IE

By Dr. Sara Dong @swinndong via Febrile [febrilepodcast.com @febrilepodcast]

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