Lactic Acidosis - Classification and Differential Diagnosis
Type A Lactic Acidosis: Inadequate Oxygen Delivery
 • Anaerobic muscular activity: Exercise, Generalized convulsions
 • Tissue hypoperfusion: Cardiac arrest, Regional hypoperfusion, Shock
 • Reduced tissue oxygen delivery: Hypoxemia, Anemia
Type B Lactic Acidosis: No Evidence of Inadequate Tissue Oxygen Delivery
 • Associated with underlying disease:  Diabetic failure, Hepatic failure, Infection, Leukemia, Lymphoma, Pancreatitis, Renal failure, Short bowel syndrome, Thiamine deficiency
 • Associated with drugs and toxins: Acetaminophen, Anti-retroviral drugs, Beta-agonists, Biguanides, Carbon monoxide, Cyanide, Epinephrine, Fructose, Isoniazid, Lactate-based dialysate, Metformin, Methanol, Nitroprusside infusion, Salbutamol, Salicylates, Sorbitol
 • Associated with inborn errors of metabolism

doi: 10.1177/0885066620982585

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