DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have mild mucosal involvement, rarely with erosions
 • CBC: Eosinophilia and atypical leukocytosis
 • Hepatitis: 50% or more
 • Kidney: Tubulointerstitial nephritis
 • Skin biopsy: Dermal edema with infiltration by lymphocytes and eos
SJS/TEN:
 • Latency: 4-28 days
 • Rash: Painful erythematous macules with purpuric centers → vesicles/bullae → sloughing
 • Mucosal involvement: >90% have severe mucosal involvement with bleeding at 2 or more sites
 • CBC: Lymphopenia
 • Hepatitis: < 10%
 • Kidney: Prerenal azotemia
 • Skin biopsy: Full-thickness epidermal necrosis

SCVMC Internal Medicine @SCVMCMed

#DRESS #Syndrome #SJS #TEN #comparison #table #dermatology