Rapidly Progressive Glomerulonephritis (RPGN)
RPGN ...
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Description

Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
 • Low Complement: Post-strep GN, Lupus Nephritis, Cryoglobulinemia, Endocarditis, Idiopathic
 • Normal Complement: IgA nephropathy, Henoch-SchonIein Purpura
Anti-GBM antibodies (linear staining):
 • Limited to Kidney: Anti-GBM Glomerulonephritis
 • With associated pulmonary involvement: Anti-GBM Disease (Goodpasture's)
Pauci-immune mediated (Negative IF):
 • PR3-ANCA (C-ANCA): GPA >>> MPA > eGPA
 • MPO-ANCA (P-ANCA): eGPA, MPA >>> GPA

Stanford Internal Medicine Chiefs @StanfordChiefs

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Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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