Acute Kidney Injury (AKI) - Differential Diagnosis Framework

Prerenal:

 • Due to true volume loss or decreased effective arterial blood volume

 • Hypovolemia: Dehydration, GI losses, hemorrhage, diuretics, burns, 3rd spacing

 • Decreased effective arterial supply: cardiorenal, hepatorenal, sepsis

 • Drugs: NSAIDs, ACEI/ARB

Intrinsic:

 • Due to damage to the glomeruli, tubules, or interstitium

 • ATN (Acute tubular necrosis)

 • Ischemic

 • Toxic (some abx, heme pigment, contrast dye)

 • AIN (acute interstitial nephritis)

 • GN (glomerulonephritis)

Postrenal:

 • Due to damage/obstruction along the urinary tract system

 • Cellular debris

 • Kidney stone

 • Tumor

 • Prostate enlargement

 • Trauma to the urinary tract



By Dr. Liza Cholin @LouLectures



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