Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 



Caused by: Tropheryma whipplei



Symptoms and Signs:

1. Migratory poly/oligoarthralgia (80%)

2. Weight loss (90%)

3. Abdominal pain; colicky (60%)

4. Intermittent diarrhea (75%)



Diagnostic Criteria - Either one of:

 • Oculomasticatory/oculo-facial-skeletal myorhythmia OR

 • PAS-positive macrophages from a small bowel biopsy OR

 • Two different positive T. whipplei tests (PAS, PCR, or IHC) from the same specimen OR

 • One positive T. whipplei test (PAS, PCR, or IHC) from two different specimens



Matthew Ho, MD PhD @MatthewHoMD



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