SAPHO Syndrome 



SAPHO Syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized by:

 • Synovitis (inflammation of the joints)

 • Acne (Acne conglobata or fulminans)

 • Pustulosis (thick yellow blisters containing pus) often on the palms and soles

 • Hyperostosis (increase in bone substance)

 • Osteitis (inflammation of the bones)



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