Rapidly Progressive Glomerulonephritis (RPGN) 
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Description

Rapidly Progressive Glomerulonephritis (RPGN) 

 - Loss of kidney function over a short period of tirne 

 - Urinalysis with evidence of glomerular disease (hematuria, proteinuria) 

 - Crescent formation (extra-capillary proliferation in Bowman's space) 



Immune-Complex Mediated 

• Presence of immune deposits in glomeruli 

• Ex: IgA nephropathy, lupus nephritis, cryoglobulinemia, post-infectious GN 



Anti-Glomerular Basement Membrane (GBM) 

• Typically circulating autoAb against type IV collagen (alpha3 chain) 

• Linear, ribbon-like GBM staining on IF 

• No EM deposits 



Pauci-lmmune 

• Minimal immune deposits, negative IF 

• Majority anti-neutrophil cytoplasmic antibody (ANCA) + 

• c-ANCA: anti-proteinase 3 (CPR) cytoplasmic neutrophilic staining 

• p-ANCA: anti-myeloperioxidase (MPO) perinuclear cytoplasmic staining 



#Glomerulonephritis #RPGN #Classification #Differential #Diagnosis #Nephrology 
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