Atopic Dermatitis - Topical Treatment Options 

First Line: Topical Corticosteroids 

  - High Potency: Betamethasone dipropionate, clobetasol, halobetasol 

  - Medium Potency: Triamcinolone, Fluticasone 

  - Low Potency: Desonide, Hydrocortisone 

Topical Calcineurin Inhibitors 

  - Elidel (pimecrolimus) 

  - Protopic (tacrolimus) 

Phosphodiesterase-4 (PDE4) Inhibitor 

  - Eucrisa (crisaborol) 



Atopic Dermatitis is the most common form of eczema, which affects approximately 20% of children and 3% of adults. After non-pharmacologic options, first-line treatment is topical corticosteroids (TCS). Remember that all TCS are not equal, each has a different level of potency. Aside from TCS, topical calcineurin inhibitors (TCI) are available. Tacrolimus is used in more moderate/severe AD while pimecrolimus is used in mild/moderate AD. Lastly is the newest medication called crisaborole, which is a topical PDE4 inhibitor. You may have seen the commercial for this medication which emphasizes that it can be used on very different skin locations and is "steroid-free" since it's not a TCS.

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Although crisaborole is a PDE4 inhibitor, it is VERY different than roflumilast (see previous post).



Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx



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