Inherited forms of Hyperbilirubinemia

Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB and CB forms are bound by albumin in the plasma and interstitial space and by ligandin in the hepatocyte. The mechanism responsible for transporting unconjugated bilirubin into the hepatocyte has not been identified. 

Gilbert

 - Decreased UGT1A1

 - Unconjugated

Crigler-Najjar

 - Decreased/absent UGT1A1

 - Unconjugated

Dubin-Johnson

 - Decreased MRP2

 - Conjugated

Rotor

 - Decreased OATP1B

 - Conjugated



https://pubmed.ncbi.nlm.nih.gov/25214800/



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