Ankylosing Spondylitis: Extra-articular Manifestations

Ankylosing Spondylitis: Extra-articular Manifestations

 • Ocular - Inflammation of the iris, the anterior part of the eye's middle layer (uvea) -> Anterior  

 • Uveitis - Decr visual acuity, eye pain, lacrimation and photophobia

 • GI - Inflammatory ulceration of ileum and colon may be seen on endoscopy (Not Inflammatory Bowel Disease (IBO), but IBD is more common in AS patients) -> Usually asymptomatic

 • Cardiac - Inflammation of connective tissue in large vessels and heart valves -> Aortitis, Aortic regurgitation, conduction abnormalities

 • Renal - Inflammation acute phase reactant production (including serum amyloid proteins) -> Deposition of amyloid proteins in glomeruli -> Secondary Amyloidosis

 • Neurological - Ligamentous inflammation and fibrosis -> Compression of sacral nerve roots innervating the bladder and rectum -> Bladder and bowel incontinence

 • Respiratory (rare) - Inflammation in the lung interstitial tissue -> As inflammation resolves, fibrotic tissue replaces the lung interstitium -> Apical lung fibrosis

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The Calgary Guide to Understanding Disease
Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation -

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