Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 ...
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Description

Anaphylaxis: Pathogenesis

Anaphylaxis is a Type 1 hypersensitivity reaction

While the primary mechanism of anaphylaxis is mast cell activation, basophils and eosinophils may also play a role



Inappropriate mast cell activation

=> Immediate Phase (seconds-minutes)

=> Mast cell degranulation -> release of preformed mediators => 

 • Histamine

 • Lipid mediators (e.g. prostaglandins, leukotrienes)

 • Other mediators (e.g. PAF, tryptase, TNF)

 • Additional production of inflammatory mediators (e.g. cytokines, chemokines)

=> 

 • Vasodilation

 • Increased vascular permeability

 • Smooth muscle contraction in airways

 • Increased mucus secretion

 • Recruitment of inflammatory cells

 • ANS activation

=> Anaphylaxis



#Anaphylaxis #pathophysiology #immunology 
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The Calgary Guide to Understanding Disease
@TheCalgaryGuide
Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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