Oral Hypoglycemics in Diabetes Management
1  INSULIN ...
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Description

Oral Hypoglycemics in Diabetes Management

1  INSULIN SENSITIZER

 • TZD 

     - PPAR gamma agonist 

     - “_glitazone” - Pioglitaxone (Actos), Rosiglitaxone (Avandia) 

 • Biguanides

     - Inhibit gluconeogenesis, Also ↑ Sensitivity 

     - Metformin (Glucophage) 

2  INSULIN SECRETAGOGUES

 • Meglitinides

     - Stimulate β cells to secrete 

     - Repaglinide (GlucoNorm) 

 • Sulfonylureas 

     - ↑ β-cells secretion

     - Gliclazide (Diamicron), Glimepiride (Amaryl), Glyburide (Diabeta) 

3  CARB ABSORPTION INHIBITOR

 • alpha-glucosidase inhibitor 

     - Prevents polysaccharide degradation, slows gut starch absorption

     - Acarbose (Prandase) 

 • SGLT-2

     - Inhibit proximal tubule glucose reabsorption

     - Canagliflozin (Invokana) 

4 INCRETIN AGENTS

 • GLP-1 agonists 

     - Inhibit gastric emptying…↑ insulin secretion

     - Dulaglutide (Trulicity), Exenatide (Byetta), Exenatide QW (Bydureon), Liraglutide (Victroza), Lixisenatide (Adlyxin)

 • DPP-4 Inhibitors 

     - Prevents GLP breakdown by inhibiting DPP-4 ENZ

     - “__gliptin” - Sitagliptin (Januvia), Linogliptin (Trajenta) 



- Amy Chung, MD, MSc @AmyChung 



#Oral #Hypoglycemics #Diabetes #Management #pharmacology #DM2 #DMII #Classification
Contributed by

Dr. Gerald Diaz
@GeraldMD
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG:  https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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