NSAIDS and their effects on the Kidney - Pathophysiology



Arachidonic Acid metabolites into alternative pathways that modify immune function

 • Minimal Change Disease

via Prostaglandin inhibition

 • Increase Na reabsorption in Proximal, loop and distal component of Nephron: CHF, HTN, Edema

 • Inhibition of Renin release: hyporenin hypoaldo, hyperkalemic distal RTA

 • Increase H2O absorption in distal nephron: Hyponatremia

 • Vasoconstriction and decreased renal blood flow: Pre renal AKI

Idiosyncratic immune reaction

 • Acute Interstitial Nephritis

Necrosis of kidney tissue

 • Papillary Necrosis



Dr. Kenar Jhaveri @kdjhaveri



#NSAIDS #KidneyDisease #nephrology #Effects #pathophysiology #renal