Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer ...
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Description

Acute Kidney Injury (AKI) in Patients with Cancer 



Cancer Related 

• Hypercalcemia 

• Intravenous contrast 

• Lymphomatous infiltration 

• Light chain (LC) cast nephropathy 

• LC deposition disease (LCDD) 

• Heavy chain DD 

• Proximal LC tubulopathy 

• Monoclonal gammopathy of renal significance (MGRS) 

• Secondary Membranous nephropathy 

• Solid tumors 

• Secondary Minimal change disease 

• Hematologic malignancies 



Treatment Related 

• Sepsis, volume depletion 

• Hepatic sinusoidal obstructive syndrome 

• Capillary leak syndrome (Interleukin-2) 

• Tumor lysis syndrome 

• Proximal tubular injury 

• Cisplatin 

• ATN: Imatinib, ifosfomide 

• Crystal nephropathy: Methotrexate 

• AIN: Sorafenib, sunitinib , PD-Ii 

• TMA: Gemcitabine, cisplatin, bevacizumab (VEGFi), TKi 

• Hemorrhagic cystitis -> bladder outlet obstruction (cyclophosphamide) 



#Acute #Kidney #Injury #AKI #Cancer #Oncology #Differential #Diagnosis #Classification #Nephrology
Contributed by

NephSim (www.nephsim.com)
@Neph_Sim
nephsim.com is a free educational tool that uses interactive cases, media, and infographics to teach nephrology topics including glomerular diseases, acid/base disorders, kidney transplant, electrolyte abnormalities, dialysis, & more! https://twitter.com/Neph_Sim
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