Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)
49M +burning rash groins/buttocks (pic in next thread) x 1d. No fever. 120/80,HR87. Exam: b/l warm,red patch groins/buttocks; no oral/palm lesion. WBC: 9. PMH: DM (A1c 6.5%; on canagliflozin), HTN (amlodipine), taking amox for a recent ear infection. Tx of this condition?
68% got the right answer, d/c culprit drug +/- steroids. The MCQ highlights a case of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE).
SDRIFE is a drug reaction uniquely characterized by:
- symmetrical, well-demarcated, erythematous, confluent maculopapular rash/plaques in the upper/inner thighs, inguinal, gluteal areas
Other features of SDRIFE:
- also known as baboon syndrome (rash in the buttocks resembles that of baboons)
- the rash can rarely exhibit pustules, blisters, or purpura
- does not involve the palms/soles, face, or mucosal surfaces
WuidQ: Washington University ID Questions @WuidQ
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