This is a quick overview of hormonal acne treatment for the medical student and resident.
Keep in mind the combination oral contraceptives include:
Ethinyl Estradiol and Norgestimate
Ethinyl Estradiol and Norethindrone Acetate (+ Iron)
Ethinyl Estradiol and Drospirenone
Ethinyl Estradiol, Drospirenone, and Levomefolate calcium
#dermatology #treatment #photo #management #skin #hormonal #acne
1. Bosanac SS, Trivedi M, Clark AK, Sivamani RK, Larsen LN. Progestins and acne vulgaris: a review. Dermatology Online Journal. 2018;24(5). Accessed August 17, 2020. https://escholarship.org/uc/item/6wm945xf
2. Koo EB, Petersen TD, Kimball AB. Meta-analysis comparing efficacy of antibiotics versus oral contraceptives in acne vulgaris. J Am Acad Dermatol. 2014;71(3):450-459. doi:10.1016/j.jaad.2014.03.051
3. Sato K, Matsumoto D, Iizuka F, et al. Anti-androgenic therapy using oral spironolactone for acne vulgaris in Asians. Aesthetic Plast Surg. 2006;30(6):689-694. doi:10.1007/s00266-006-0081-0
4. Layton AM, Eady EA, Whitehouse H, Del Rosso JQ, Fedorowicz Z, van Zuuren EJ. Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review. Am J Clin Dermatol. 2017;18(2):169-191. doi:10.1007/s40257-016-0245-x
5. Grandhi R, Alikhan A. Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study. Dermatology (Basel). 2017;233(2-3):141-144. doi:10.1159/000471799
6. Isvy-Joubert A, Nguyen J-M, Gaultier A, et al. Adult female acne treated with spironolactone: a retrospective data review of 70 cases. Eur J Dermatol. 2017;27(4):393-398. doi:10.1684/ejd.2017.3062
7. Castelo-Branco C, Moyano D, Gómez O, Balasch J. Long-term safety and tolerability of flutamide for the treatment of hirsutism. Fertility and Sterility. 2009;91(4):1183-1188. doi:10.1016/j.fertnstert.2008.01.046
8. Bitzer J, Römer T, Lopes da Silva Filho A. The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review. Eur J Contracept Reprod Health Care. 2017;22(3):172-182. doi:10.1080/13625187.2017.1317339
9. Gollnick H, Albring M, Brill K. [The effectiveness of oral cyproterone acetate in combination with ethinylestradiol in acne tarda of the facial type]. Ann Endocrinol (Paris). 1999;60(3):157-166.
10. Lortscher D, Admani S, Satur N, Eichenfield LF. Hormonal Contraceptives and Acne: A Retrospective Analysis of 2147 Patients. J Drugs Dermatol. 2016;15(6):670-674.
11. Lessner E, Fisher S, Kobraei K, et al. Spironolactone and topical retinoids in adult female cyclical acne. J Drugs Dermatol. 2014;13(2):126-129.